• Introduction Double strand break DSB is the most

  2019-08-15

  

  Introduction Double strand break (DSB) is the most deleterious damage that threats DNA integrity. This frequent damage arises from environmental stress like UV, chemical agents or ionizing radiations (IRs). Although environmental stress does not lead directly to DSB, it produces maybe damage, muta

• In the past few years

  2019-08-15

  

  In the past few years, DNA-templated fluorescent metal nanoparticles have been developed as ideal alternatives to organic dyes due to their facile synthetic process, outstanding optical properties, ultrafine size, and fine biological compatibility. Since the first successful demonstration of DNA-tem

• Multivariate models take interactions between cytokines into

  2019-08-15

  

  Multivariate models take interactions between cytokines into account and were used to accurately distinguish samples from different time points in pregnancy. The distinction accuracy did not increase with increasing time between the gestational time points, indicating that the cytokine development d

• Natural and synthetic glucocorticoids perform their biologic

  2019-08-15

  

  Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.

• SPR was used to measure biomolecular kinetic interactions

  2019-08-15

  

  SPR was used to measure biomolecular kinetic interactions between TERRA G-quadruplex and ligand in the present study. SPR is a widely used method, but cannot tell which specific type of interaction happened. Compounds with similar structures probably have similar mechanism of interaction, while comp

• DDR although normally expressed in cells with mesenchymal fe

  2019-08-15

  

  DDR2, although normally expressed in pitavastatin with mesenchymal features, has also been reported to enhance EMT. In A549 lung cancer cells, TGFβ1 increases the expression of type I collagen and DDR2. Knocking-down COL1A1 or DDR2 with siRNA is sufficient to inhibit EMT and cell migration induced b

• br Expression data suggest involvement of additional TRIMs

  2019-08-15

  

  Expression data suggest involvement of additional TRIMs in heart function Given the complexity of the cardiac function, involved molecular pathways and processes, and the fact that only a few of the TRIMs have thus far been shown to have a cardiac role, we hypothesized that there would be more TR

• As discussed in the introduction many pregnant women take me

  2019-08-15

  

  As discussed in the introduction, many pregnant women take medications such as nifedipine and indinavir, which are considerably metabolized by CYP3A [26]. Previous reports have also shown increased CYP3A activity following pregnancy [7], [9], which is consistent with our results. However, previous s

• br Financial Support We would like to acknowledge financial

  2019-08-15

  

  Financial Support We would like to acknowledge financial support by the National Natural Science Foundation of China (grant numbers 81672778 and 81372165) and Natural Science Foundation of Beijing Municipality (grant number 5142009). Acknowledgements Introduction The process of spermatogen

• In studies directed toward the development

  2019-08-14

  

  In studies directed toward the development of sequence-specific major-groove binding small Pleuromutilin [11], we desired a non-intercalating molecular scaffold that could direct attached moieties into the major groove. As an initial step toward this goal, we wished to study the DNA binding mode a

• br Results and discussion br Conclusion

  2019-08-14

  

  Results and discussion Conclusion Analogues of 1,2,4-triazole and 1,3,4-oxadiazole have been designed, synthesized and characterized. To avoid late stage failure, it is important to study the preliminary pharmacokinetic parameters. The results of pharmacokinetic data suggested that, all molec

• To elucidate the potential mechanism underlying osteosarcoma

  2019-08-14

  

  To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine induced pluripotent stem cells and apoptosis in human osteosarcoma cells after palbociclib treatment. The results showed that osteosarcoma cells were a

• gstp1 Cells expressing the CDK S D mutant exhibit

  2019-08-14

  

  Cells expressing the CDK5 S47D mutant exhibit impaired migration and enhanced proliferation: Finally, we wished to determine the functional significance of this phosphoevent. Multiple studies have implicated active CDK5 in promotion of cell migration [9,16,[21], [22], [23], [24]] and in one study th

• Furthermore in silico physicochemical characters and pharmac

  2019-08-14

  

  Furthermore, in silico physicochemical characters and pharmacokinetic parameters for the synthesized compounds were predicted using dedicated computer software [34], [35], [36] to ensure successful in vivo therapeutic activity. Practical logP testing was performed and compared to the theoretical val

• Several TERRA binding proteins have

  2019-08-14

  

  Several TERRA-binding proteins have also been discovered, especially telomeric duplex DNA binding proteins TRF1 and TRF2, pointing to a significant role of TERRA in more general chromosome biology [14], [20], [21]. TRF2 is a key component of Shelterin that protect chromosome termini [22]. Telomeres

14867 records 972/992 page Previous Next First page 上5页 971972973974975 下5页 Last page