• Another notable finding in this study is that Cbl b

  2020-11-23

  

  Another notable finding in this study is that Cbl-b-mediated ubiquitination accelerates the degradation of phosphorylated DDR2. Cbl family has been documented to facilitate RTK degradation either in proteasome through K48-linked poly-ubiquitination or in lysosome through mono-, multiple mono- and K6

• Due to cell cell interactions high concentrations of

  2020-11-23

  

  Due to cell-cell interactions, high concentrations of LTs can be locally generated in a short period of time during an inflammatory response, thus potentiating LT function. The cellular communication can be mediated between immune cells as well as between immune cells other cell types. Several studi

• As described above when EGCG

  2020-11-23

  

  As described above, when EGCG was orally administered, CYP3A expression in the liver decreased; however, the CYP3A expression level in the intestine was unchanged (Fig. 3). Although we remain speculative, one reason for this may be that because the level of intestinal bacteria in the upper part of t

• Taking into account that Gr

  2020-11-23

  

  Taking into account that Gr dysfunction is involved in the molecular mechanisms underlying HPA axis disorder (Li et al., 2017b) and Gr activity has been reported to be lowered in patients with severe mood disorders (Rush et al. 1996) and in adult rats (Green et al. 2016), PFOS could alter HPA axis a

• These contrasting results observed with intra BNST combined

  2020-11-23

  

  These contrasting results observed with intra-BNST combined injections of NOC-9 and CP 376395 on freezing (in the novel arena) versus anxiety-related behavior (in the EPM) suggest that CRF neurotransmission within this forebrain limbic site could be mainly involved in the modulation of more subtle a

• A widely accepted mechanism to differentiate hESCs into card

  2020-11-23

  

  A widely accepted mechanism to differentiate hESCs into cardiomyocytes is through perturbation of the canonical Wnt/β-catenin pathway. Initial Wnt activation is required to form the Carbetocin [3]. Thereafter, it is believed that inhibition of the canonical Wnt/β-catenin pathway is pivotal for card

• Our published results also show that

  2020-11-23

  

  Our published results also show that the Y2 and the Y5, but not the Y1, receptors mediate NPY-induced excitation-secretion coupling in EECs (Abdel-Samad et al., 2012). Thus, it is highly important to consider controlling ET-1 circulating level via blockade of Y2 and/or Y5 receptor activation (Abdel-

• E-64 TgTCEA from petals TgTCEA and TgTCEB from pollen grains

  2020-11-20

  

  TgTCEA from petals (TgTCEA1) and TgTCEB from pollen grains (TgTCEB1) were used throughout the study. The recombinant enzymes were expressed in , and purified as the His-tag-free forms as described previously., Enzyme reactions were performed at 4 mM substrates under the same conditions as described

• br Conclusion Conventional surgical excision of the tumoral

  2020-11-20

  

  Conclusion Conventional surgical excision of the tumoral lesions is the primer therapy for the BCC. Recurrence rates are significantly higher for surgical margin positive lesions that also creates challenges for the surgeons on obtaining best cosmetic and oncologic results. In our study, EGFR Can

• br Results br Discussion The process by which MBCs

  2020-11-20

  

  Results Discussion The process by which MBCs differentiate from GC B cell precursors remains mostly uncharacterized, in large part because of the uncertainty surrounding the nature of the precursor Sodium Orthovanadate within the GC. The identification here of a distinct subset of GC B cells,

• br Results br Discussion Analysis

  2020-11-20

  

  Results Discussion Analysis of EBI2 expression showed that EBI2 is highly expressed in central memory CD8+ T cells that is in line with previous data from human T cells in which these Oxaliplatin express higher levels of EBI2 than naive or effector memory CD8+ T cells (Hannedouche et al., 201

• br Materials and methods br Results br

  2020-11-20

  

  Materials and methods Results Discussion The phosphatidylinositol 3-kinase-like protein kinases, ATM, ATR, and DNA-PK, have all been implicated in H2AX phosphorylation in response to different stimuli [37], [41], [42], [43], [44], [45]. We show here that H2AX is phosphorylated in rodent and

• Pol is responsible for the bulk of leading strand

  2020-11-20

  

  Pol ε is responsible for the bulk of leading-strand synthesis in vivo (Daigaku et al., 2015, Nick McElhinny et al., 2008, Pursell et al., 2007) and physically associates with CMG (Langston et al., 2014, Sengupta et al., 2013, Sun et al., 2015, Zhou et al., 2017). Furthermore, leading-strand synthesi

• br Introduction Acinetobacter baumannii is

  2020-11-20

  

  Introduction Acinetobacter baumannii is a gram-negative opportunistic pathogen that causes nosocomial infections including pneumonia and bloodstream infections which is associated with an increased mortality and multi-drug resistance [[1], [2], [3]]. A. baumannii was rated as one of the critical

• DNA methylation is associated with

  2020-11-20

  

  DNA methylation is associated with transcriptional silencing of tumor suppressors or other genes important for normal cellular function and plays an important role in the development of cancer and other diseases (such as breast and colorectal cancers) [19]. DNA methyltransferases (MTases) are a fami

14913 records 742/995 page Previous Next First page 上5页 741742743744745 下5页 Last page