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br Acknowledgements We thank Jeffrey D Konowalchuk and John
2021-01-22
Acknowledgements We thank Jeffrey D. Konowalchuk and John Sony Robbins for their technical assistance. This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC) grants to DRB (RGPIN-2013-355303) and MB (RGPIN-2014-96395). AMR was supported by NSERC Vanier Doct
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Based on the finding described
2021-01-22
Based on the finding described above, the present study was designed to investigate the effects of specific CRF receptors, CRF1 and CRF2, in the BLA and CeA on the duration of TI in guinea pigs (Cavia porcellus). To this end, we evaluated whether administration of the CRF1 inno-206 antagonist CP-37
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Conclusions br Acknowledgements The study was
2021-01-22
Conclusions Acknowledgements The study was supported by a grant from the Argentine National Agency for the Promotion of Science and Technology (ANPCyT) (PICT 2012-2649). N.R.S., H.H.O., G.J.H. and F.R. are research career members and N.C.G., E.A., E. H., F.M.R., are fellows of the National Scien
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Many countries in all over the
2021-01-22
Many countries in all over the world generate a large amount of RHA from uncontrolled and controlled burning. RHA is a pozzolanic material due to this high percentage of SiO2 in RHA. Rice husk ash, as a mineral additive, is produced by burning rice husks, which are obtained in the rice milling indus
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In conclusion we have shown that the
2021-01-22
In conclusion, we have shown that the cellular effects produced by SFN in NSCLC Creatinine are largely mediated by SFN-induced production of ROS. Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels pro
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br Electron transfer pathway Intramolecular or inter domain
2021-01-21
Electron transfer pathway Intramolecular (or inter-domain) electron transfer (IET) in CDH has been studied in much depth [], and similar IET occurs in CcPDH, from the PQQ cofactor in the AA12 domain to the heme b in the AA8 domain. When two kinds of electron acceptors are used for measuring enzym
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The present study also showed that EP deficiency
2021-01-21
The present study also showed that EP2 deficiency and EP4 antagonism significantly suppressed psoriatic Rebastinib in an imiquimod model. Notably, however, the combined EP2 deficiency and EP4 antagonism did not completely suppress ear swelling in this model, possibly because there is the IL-17–inde
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Notably we demonstrated that EP
2021-01-21
Notably we demonstrated that EP2/EP4 receptor-coupled activation of the cAMP signaling pathway accounted for both up-regulation of COX-2 and down-regulation of LOX, which is consistent with the roles of the cAMP signaling pathway in regulation of COX-2 and LOX by PGE2 in a number of other tissues or
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Introduction The carnitine choline acyltransferase
2021-01-20
Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) Tenofovir Disoproxil Fumarate and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this fam
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During ischemia the impact of CK on mitochondria varies
2021-01-20
During ischemia, the impact of CK2 on mitochondria varies in different organs/tissues. For example, CK2α upregulation during ischemia leads to disrupted mitochondrial homeostasis and mediates cardiomyocyte ischemic injury [31]. Specifically, ischemia/reperfusion (I/R) progressively increases CK2α to
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Arsenic is an endocrine disruptor with estrogenic
2021-01-20
Arsenic is an endocrine disruptor with estrogenic activity. Further study has shown that arsenic exposure can significantly increase the expression of estrogen receptor-related genes, steroid metabolism-related enzymes and lung cancer-related genes in the lung tissues of female mice on the occurrenc
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Sampling sediments is usually performed with grab
2021-01-20
Sampling sediments is usually performed with grab corers [16], [29]. The digested sludge analyzed by Ternes et al. [16] was taken directly from the digester and the activated sludge was obtained by brain metabolism of the slurry of STPs [16]. Collected samples are transported under cooled condition
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While agnathans appear to have reduced
2021-01-20
While agnathans appear to have reduced their Ednr repertoire to the Ednra gene (that may have been amplified in the Arctic lamprey), gnathostomes in general have been relatively inert to Ednr gene loss. Strikingly, the only Ednr gene that has been lost repeatedly is EdnrB2 (lost in therian mammals,
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CYP contributes to the metabolism of more
2021-01-20
CYP450 contributes to the metabolism of more than 90% of currently available drugs (Shapiro and Shear, 2002). Currently, CYP1A is the most studied xenobiotic-metabolizing isoform in fish and is often used as a biomarker for early effects of pollutants in aquatic organisms (Havelkova et al., 2007). T
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STRING protein interactions were used to highlight
2021-01-19
STRING protein interactions were used to highlight enzymes directly associated with DHODH (Fig. 10) (Szklarczyk et al., 2015). The reported protein-protein associations are primarily within the de novo nucleotide synthesis pathways (CAD, carbamoyl phosphate synthetase 1, uridine monophosphate synthe
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